COX-2 inhibitors, also known as selective COX-2 inhibitors, are nonsteroidal anti-inflammatory drugs (NSAIDs) that treat inflammatory pain. They’re available by prescription and may be easier on ...

They searched for randomized controlled trials comparing the risk of GI adverse effects in patients taking nonselective NSAIDs, selective cyclooxygenase (COX)-2 inhibitors, or nonselective NSAIDs ...

For example, celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, has shown benefits for osteoarthritis in vitro without affecting healthy cartilage. The anti-inflammatory function of NSAIDs ...

Studies of the structural basis of COX-2 selectivity have been difficult due to the flexibility of the substrate, arachidonic acid and high homology (84%) between COX-1 and COX-2 in mammalian species.

Although COX-2-selective drugs generally cause fewer gastric ulcers than non-selective NSAIDs, these events aren't completely eliminated, and the residual side-effect rate still may be high," said ...

The association is not new, but it adds another group of patients to the list of those who may be vulnerable on NSAIDs. In a 2013 meta-analysis from the Coxib and Traditional NSAID Trialists’ (CNT) ...

The use of COX-2 selective inhibitors reduces the risk of upper gastrointestinal clinical events, compared with NSAIDs, in patients taking PPIs or low-dose aspirin; however, this result was driven ...

Traditional NSAIDs -- like aspirin or ibuprofen -- block the action of both COX-1 and COX-2, which is why some people suffer from stomach upset after taking them, the AAOS said.

NSAIDs stop proteins called cyclooxygenase, known as COX, and fall into two classes: “selective” COX-2 inhibitors (celecoxib, etoricoxib, or rofecoxib) and “nonselective” COX-1/COX-2 ...

The increased risk for ibuprofen was 24% and for the now withdrawn selective COX-2 inhibitor rofecoxib was 32% (both p < 0.05). [22] ...

Well, COX-2 inhibitors are NSAIDs, but they're newer NSAIDs that were developed to avoid some of the stomach problems that the older NSAIDs caused.<p>So, NSAIDs increase the risk of stomach ulcers ...

Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity Kathleen M Knights; Arduino A Mangoni; John O Miners Disclosures Expert Rev Clin Pharmacol. 2010;3 (6):769 ...