Here we describe a novel 3D NK cell mediated cytotoxicity (CMC) assay. HCT116 colorectal cancer cells were embedded within a collagen hydrogel of defined concentration and thickness, mimicking in vivo ...

Figure 3 shows that the Guava Cell Toxicity Assay detected CMC, but, as expected, higher effector-to-target ratios were necessary than for the NK experiments. IL-2 is known to induce a dose ...

NK cells trigger an anti-tumor immune response called antibody-dependant cellular cytotoxicity (ADCC) when activating receptors, such as CD16, attach to monoclonal antibodies (mAbs) on target cells.

Blocking NK cell inhibitory self-recognition promotes antibody-dependent cellular cytotoxicity in a model of anti-lymphoma therapy. (2008) J. Immunol., 180:6392-6401.

More information: Yizhe Sun, et al. Adaptive NK Cells Exhibit Tumour-Specific Immune Memory and Cytotoxicity in Ovarian Cancer, Cancer Immunology Research (2025).

Title: Redirecting NK cell cytotoxicity by Innate Cell Engagers: A differentiated and innovative approach compared to CAR-NK cells Authors: Sonya Ioana Ciulean, Julia Uhlig, Christian Breunig ...