Cite this: Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity - Medscape - Nov 01, 2010.

Pharmacology of NSAIDs NSAIDs act by inhibiting cyclooxygenase, an enzyme involved in the formation of various prostanoids with a wide variety of pharmacologic actions. 11 The COX-2 selective NSAIDs ...

Surprisingly, the researchers found that NSAIDs exacerbate C. difficile infection independent of COX inhibition and instead through off-target effects on mitochondria. They did so by treating colonic ...

Although there are minor differences in the mechanism of action of NSAIDs, they are all inhibitors of the cyclo-oxygenase enzyme (COX); thus, they prevent the conversion of arachidonic acid into ...

Gasdermin C activation boosts type II immunity against helminths, and NSAIDs may someday offer a novel, repurposed treatment ...

Koo noted that since many researchers and clinicians have proposed that NSAIDs are effective in Alzheimer’s disease by inhibiting COX enzymes and therefore inflammation, the UCSD/Mayo team ...

NSAIDs weaken two forms of the coxib enzymes and, of the two it is only one, COX-1, which causes adverse effects. They also inhibit COX-2 enzymes, which are synthesised from arachidonic acid in ...

NSAIDs work by blocking an enzyme called cyclooxygenase-2 or COX-2 which is essential for prostaglandin synthesis, thereby relieving some of the effects of pain and fever.