Pharmacology of NSAIDs NSAIDs act by inhibiting cyclooxygenase, an enzyme involved in the formation of various prostanoids with a wide variety of pharmacologic actions. 11 The COX-2 selective NSAIDs ...

Gasdermin C activation boosts type II immunity against helminths, and NSAIDs may someday offer a novel, repurposed treatment ...

Although there are minor differences in the mechanism of action of NSAIDs, they are all inhibitors of the cyclo-oxygenase enzyme (COX); thus, they prevent the conversion of arachidonic acid into ...

NSAIDs (non-steroidal anti-inflammatory drugs), such as aspirin, inhibit cyclooxygenase enzymes (COX-1 and COX-2) that catalyze formation of prostaglandins from arachidonic acid and they have been ...

Surprisingly, the researchers found that NSAIDs exacerbate C. difficile infection independent of COX inhibition and instead through off-target effects on mitochondria. They did so by treating colonic ...

COX-2 enzymes, however, are implicated in prostaglandin production that causes inflammation. Since most NSAIDs block both COX-1 and COX-2 enzymes, they can prevent the body from producing ...

Koo noted that since many researchers and clinicians have proposed that NSAIDs are effective in Alzheimer’s disease by inhibiting COX enzymes and therefore inflammation, the UCSD/Mayo team ...