Figure 1: Genes governing the development of the preimplantation mouse embryo. Most gene-expression studies have so far pointed towards changes in Tr gene expression during blastocyst dormancy or ...

After the targeting vector is made, it is used to knock out one copy of the target gene in mouse embryonic stem (ES) cells (Figure 2). But why must mouse ES cells be used? Why can't the targeting ...

In a groundbreaking study, scientists have created a mouse using stem cells powered by genes that originated from ancient ...

Chimpanzee naive pluripotent stem cells (PSCs) can now be grown in cellular cultures, reveals a recent study. They successfully created chimpanzee early embryo models, called 'blastoids,' and found ...

An international research team has provided a detailed insight into how the spatial organization of genetic material is established in the cell nucleus of early embryos within the first hours after ...

Organoids are made to model human organs and are promising for research and therapy, but there are limitations in their growth and function. A recent study by researchers at The University of Tokyo ...

The embryo space is mapped out by the different expression patterns of these genes, each vital for normal development; a mutation in any one gene can be lethal. External view of 10.5 day mouse ...

Knockout and knock-in mouse lines can be generated using gene targeting in embryonic stem cells with chimera production or CRISPR genome editing in mouse zygotes. For projects involving CRISPR genome ...

(The embryos were destroyed as per ethical requirements of the experiment.) He used a controversial gene-editing technique ... to repair the mutation in mouse embryos. Mitalipov says he also ...

An international research team led by Helmholtz Munich has, for the first time, provided a detailed insight into how the spatial organization of genetic material is established in the cell nucleus of ...

An international research team led by Helmholtz Munich has, for the first time, provided a detailed insight into how the ...