As we age, the genes in our cells accumulate more mutations. This is one of the contributory factors to age-related diseases ...

Changes in how brain cells generate energy may drive the development of Alzheimer's disease and influence how patients ...

Mitochondrial genes have evaded scientists' efforts to correct such mutations, Mitalipov said.

Mitochondrial dysfunction’s central role in AD pathology highlights the critical need for targeted interventions aimed at restoring mitochondrial health. miRNA-based therapies present a particularly ...

Mitochondria provide the host cell with energy, somewhat as batteries do to machines. Unlike all other cell components, but again like bacteria (and despite having most of their genes located in ...

A genetic test has been developed, providing a rapid diagnosis of mitochondrial disorders to identify the first patients with inherited mutations in a new disease gene. The team of medics and ...

Mitochondrial genes on both DNA strands are transcribed in a polycistronic manner: Large mitochondrial mRNAs contain the instructions to build many different proteins, which are encoded one after ...

The genes in our cells’ mitochondria are passed on in a different way than the vast majority of our DNA. New studies shed light on how the unique process isn’t derailed by mutations.

Mutations in the mitochondrial gene mt-ATP6, which encodes an essential part of the mitochondrial motor known as ATP synthase that generates cellular energy, are much more variable than previously ...

Scientists report a new gene-editing tool that can target DNA in mitochondria (red). Previous editors were only effective in nuclei (blue). Tslil Ast/Mootha Lab By Jack J. Lee July 13, 2020 at 9:00 am ...

Mutant mtDNA enhances the generation of reactive oxygen species (ROS), from the mitochondrial electron transport chain, that induces mutations in nuclear genes as well as mitochondrial genes.