The team used a technique called cryogenic electron microscopy to reveal in fine detail how the molecule interacted with each mutant and with healthy ... rare conditions that harm mitochondrial DNA.

These organisms share a unique mitochondrial DNA structure that is called kinetoplast DNA, or kDNA. ... Electron microscopy studies that began in the 1970s revealed that some kinetoplastids, ...

Electron Microscopy. This page provides educational resources, events, news and products related to electron microscopy techniques and applications, including SEM, TEM and cryo-EM. Electron Microscopy ...

When mitochondria fail, the consequences can be devastating – particularly for children with genetic disorders that rob cells of their ability to produce energy.. Now, researchers at the University of ...

The POLG gene regulates the production of DNA polymerase gamma, an enzyme that copies mitochondrial DNA. Without it, ... including by means of cryo-electron microscopy.

In a new study published in Nature on May 29, researchers developed a novel imaging approach by integrating two microscopy techniques—single-particle analysis and cryo-electron tomography (cryo ...

Now biologists have discovered that it happens early—in fact, human sperm's few mitochondria contain virtually no DNA at all. The findings were published in a recent issue of Nature Genetics .

Since a lack of mitochondrial DNA is also seen in other mitochondrial, age-related, and neurodegenerative diseases, substances similar to PZL-A may gain broader therapeutic use.

For example, regions of the genome that are rich in guanine bases (represented by G in the DNA code) can fold into a DNA structure called a G-quadruplex, or G4 for short, which is more compact than ...