Recent studies challenge the traditional view of aging as a gradual process, revealing that human aging occurs in sudden ...

As we age, the genes in our cells accumulate more mutations. This is one of the contributory factors to age-related diseases ...

Mitochondrial DNA mutation accumulation may not be a determining factor in aging Date: May 29, 2025 Source: University of Tsukuba Summary: Mutations accumulated in mitochondrial DNA associated ...

Mitochondria are specialized structures within cells that are primarily responsible for energy production but that also play ...

Type 2 diabetes (T2D) is a global metabolic epidemic driven by insulin resistance (IR), chronic inflammation, and β-cell ...

New research shows that cells in high-energy-demanding tissues respond to mitochondrial dysfunction through a sophisticated ...

This collection invites content on mitochondria in the context of aging - from mechanistic studies to disease models and tool development to relevant therapeutic modalities.

A new study explains how mitochondria act as “reservoirs” to store NAD for cells to use, which could help scientists come up with NAD-boosting therapies to combat aging and age-related diseases.

The continued loss of skeletal muscle mass and strength is an undeniable element in aging.1,2 Once reaching age 40, adults lose around 8 % of their muscle mass per decade. This increases to 15 % ...

Mutations accumulated in mitochondrial DNA associated with aging were earlier believed to cause aging by decreasing the energy-producing function (mitochondrial respiratory function). In this ...

This Collection brings mitochondria into focus within the aging field, emphasizing their central role in cellular senescence, local and systemic dysfunction, and age-related disease.