Pyramidal neuron subtype diversity governs microglia states in the neocortex. Nature, 2022; DOI: 10.1038/s41586-022-05056-7 ...

Without the receptor, ADGRG1, the microglia barely nibbled on the toxic protein. Using a mouse model of Alzheimer's disease, ...

Therefore, microglia should be considered an important regulatory cell type of brain development via these special interaction sites and beyond.

Nurturing developing neurons: How microglia, the main immune cells of the brain contribute to brain development by interacting with newborn neurons Institute of Experimental Medicine ...

In their new study, the researchers wanted to investigate how APOE4 affects interactions between microglia and neurons. Recent research has shown that microglia play an important role in modulating ...

Next, Baskakov will study the mechanisms underlying this microglia-neuron interaction. He noted that unlike mouse models of Alzheimer’s and similar neurodegenerative diseases, prion-infected mice have ...

The team observed α-Syn aggregates moving from aggregate-burdened neurons to microglia, which they think reduces neuronal cell stress and likely permits aggregate degradation by microglia. 5 When ...

How microglia contribute to Alzheimer's disease A breakdown of lipid metabolism in these brain cells promotes inflammation and interferes with neuron activity, a new study finds Date: August 4 ...

"We also find that the interaction of neuron cells with macrophages or microglia in the Alzheimer's disease model leads to increased secretion of pro-inflammatory cytokines," said Prof. LU.