COPENHAGEN, Denmark, Dec. 01, 2021 (GLOBE NEWSWIRE) -- The first evidence of high dose methotrexate related toxicity (HDMTX) in Spain was presented today at Virtual ISPOR Europe 2021, a global ...

High-dose methotrexate (HDMTX; >500 mg/m 2) is a dosing strategy used to treat various cancers, including primary central nervous system lymphoma. 1 When given as a bolus (defined as infusion <6 hours ...

Source Reference: Muanda FT, et al "Low-dose methotrexate and serious adverse events among older adults with chronic kidney disease" JAMA Netw Open 2023; DOI: 10.1001/jamanetworkopen.2023.45132.

Impact of Prophylactic Trimethoprim-Sulfamethoxazole on Clearance of High-Dose Methotrexate in Adult Patients The following represents disclosure information provided by authors of this manuscript.