Further analyses using Schwann cells indicated that the pyruvate starvation-induced cell death under high-glucose milieu may result from the following sequential metabolic disturbances; 1) reduced ...

Moran and his colleagues now report that a one-pot set of reactions involving ferrous iron and two simple molecules, pyruvate and glyoxylate, can generate all five universal metabolites (Nature ...

The pyruvate dehydrogenase complex (PDHc) plays a key role in metabolism by linking glycolysis to the tricarboxylic acid cycle and converting pyruvate into acetyl-CoA. However, due to its large ...

Mitochondrial pyruvate import serves as a critical step in cellular energy metabolism, linking cytosolic glycolysis to mitochondrial oxidative phosphorylation. Disruptions in this pathway can ...

Osaka, Japan - Serine racemase (SRR) is a multifunctional enzyme that carries out several different reactions in human cells, including the conversion of L-serine into pyruvate. Despite already ...