I think that that’s not unique to ulcerative colitis. That’s true in Crohn’s disease. So, IBD globally, but also in many other disease states.

We had the IL-1223 mechanism with ustekinumab (Stelara, Janssen), and the IL-23s are some of the most recent, spinning off that IL-1223 idea.

Relevant biomarkers include cytokines and targets such as IL-4, IgE, IL-5, IL-13, IL-33, and TSLP (Figure 2). A number of ...

Front-line drug for ulcerative colitis found to have additional mechanism of action that until now remained elusive by Delthia Ricks, Phys.org Editors' notes ...

If you had invested money in Abivax (NASDAQ: ABVX) at the beginning of the year, you would be sitting pretty right now. The ...

Home News GlobeNewswire Microbiotica unveils multiple mechanisms by which MB310, in clinical development for the treatment of ulcerative colitis, protects the intestinal barrier ...

This may thus represent a new mechanism of disease in which TMEM219 overactivation induces intestinal stem cell death and prevents mucosal renewal during inflammation.

This may thus represent a new mechanism of disease in which TMEM219 overactivation induces intestinal stem cell death and prevents mucosal renewal during inflammation.

This included novel data demonstrating that different strains induce regulatory T-cells by different mechanisms. MB310 is in a Phase 1 study COMPOSER-1, with data readout expected by the end of 2025.