Discover 8 ways mast cell activation syndrome causes widespread symptoms from digestive issues to brain fog, often mistaken ...

Mast cell activation syndrome (MCAS) is a condition in which mast cells—a type of white blood cell that plays a key role in ...

Caroline Cray was diagnosed with mast cell activation syndrome in May 2019 after repeated anaphylactic episodes Jordan Greene is Society and Culture writer-reporter at PEOPLE. She has been working ...

The disease course is highly variable ... IgG autoantibodies target IgE or its receptor on mast cells, triggering activation. These mechanisms lead to the release of histamine, leukotrienes ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

At the recent AAAAI/WAO meeting, Blueprint Medicines Corp. presented the in vitro and in vivo characterization of BLU-808, a selective inhibitor of wild-type KIT, a transmembrane receptor tyrosine ...

Systemic mastocytosis (SM) is a rare disease driven by the KIT D816V mutation in about 95 percent of cases. Uncontrolled proliferation and activation of mast cells result in chronic, severe and ...

Emerging therapies will be targeted to those patients with reversible disease. The paradigm of stellate cell activation provides an important framework for defining therapeutic targets.