The classical pathway is activated by binding of the ... a fibrinogen-like and a collagen-like domain), as well as by mannose-binding lectins, triggers the activation of the complement system ...

Activation of the lectin pathway of complement is mediated by mannose-binding lectin, which is a pattern-recognition receptor specific for microbial carbohydrates. Mannose-binding lectin is ...

Variant alleles of the mannose-binding lectin gene are associated with SLE as well as with severe atherosclerosis. We determined whether mannose-binding lectin variant alleles were associated with ...

the alternative pathway or the mannose binding pathway. IgM or IgG immune complexes activate the classical pathway. The alternative pathway is constitutively active but held in check by inhibitors ...

The researchers next measured the levels of various products of glucose metabolism and concluded that mannose inhibits key enzymes involved in essential metabolic pathways, all of which rely on ...

In May Journal of Medical Genetics Gabolde and colleagues from Hôpital Robert Debré, Paris report that an independent genetic factor — the mannose binding lectin (MBL) gene — influences the severity ...

PMM2 converts mannose-6-phosphate to mannose-1-phosphate, which is an essential sugar molecule in the N-glycosylation pathway and is crucially important for proper glycoprotein structure and function.