The mannose-binding lectin pathway can be activated by C3 hydrolysis or antigens without the presence of antibodies (non-specific immune response). In all three pathways, C3-convertase cleaves and ...

Mannose-binding lectin (MBL) is a critical serum protein of the innate immune system that recognises distinct carbohydrate signatures on pathogens, initiating the lectin pathway of the complement ...

When mannose-binding lectin recognizes an invading pathogen, it initiates the lectin complement cascade by activating MASP-2 and its counterpart, MASP-1. When MASP-2 and MASP-1 are activated, they ...

The lectin pathway of the complement system is initiated by mannose-binding lectin (MBL)-associated SPs (MASP)-1, and MASP-2, which are known to be present as proenzymes in blood. The third SP of the ...

Activatability of the lectin pathway is highly dependent on the level of its key pattern-recognition molecule, mannose-binding lectin (reviewed in ). The serum functional MBL concentration shows high ...

Both pathways are initiated by complexes consisting of collagenous proteins and serine proteases of the mannose-binding lectin (MBL)-associated serine protease (MASP)/C1r/C1s family. It has been ...

Mannose-binding lectin may activate complement by means of the lectin pathway when interacting with mannose-binding lectin–associated serine proteases and can directly opsonize pathogens and ...

Background— Complement consists of a complex cascade of proteins involved in innate and adaptive immunity. The cascade can be activated through 3 distinct mechanisms, designated the classical, ...

Mannose binding lectin is a lectin instrumental in the innate immunity. ... The mannose-binding lectin-pathway is involved in complement activation in the course of renal ischemia-reperfusion injury.

The complement system is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promotes ...