The mannose-binding lectin MBL2 plays an important role in the innate immune system. It binds carbohydrates surface, acts as an opsonin and activates the complement system. With the aim of ...

Chronic liver disease is a major complication of cystic fibrosis (CF) and factors other than the deletion of ΔF508 (which causes CF) may control the development of liver damage. In May Journal of ...

Mannose-binding lectin is a liver-derived serum protein involved in innate immune defense. The ligands for mannose-binding lectin are mannose and N -acetyl glucosamine oligosaccharides, expressed ...

Epidemiology and Infection, Vol. 142, No. 10 (OCTOBER 2014), pp. 2195-2206 (12 pages) Several studies have evaluated the association between mannose-binding lectin (MBL) polymorphisms and sepsis.

When mannose-binding lectin recognizes an invading pathogen, it initiates the lectin complement cascade by activating MASP-2 and its counterpart, MASP-1. When MASP-2 and MASP-1 are activated, they ...

The mannose-binding lectin pathway can be activated by C3 hydrolysis or antigens without the presence of antibodies (non-specific immune response). In all three pathways, C3-convertase cleaves and ...

Julie Beneteau, Denis Renard, Laurent Marché, Elise Douville, Laurence Lavenant, Yvan Rahbé, Didier Dupont, Françoise Vilaine, Sylvie Dinant, Binding Properties of the N-Acetylglucosamine and ...

SUMMARY The mannose-binding lectin associatedprotease-3 (MASP-3) is a member of the lectin pathway of the complement system, a key component of human innate and active immunity. Mutations in MASP-3 ...

Immunoglobulin A (IgA) nephropathy is the most prevalent glomerulonephritis worldwide that does not have a specific treatment. Its pathogenesis is complex and not well understood, but there is ...

In patients with HSCT-TMA, the lectin pathway is activated. 10 Mannan-binding lectin-associated serine protease-2 (MASP-2) is the effector enzyme of the lectin pathway and an activator of the ...

About the study In the present study, researchers assessed the effect of D2, a recombinant fragment of the lectin-binding region of Gal-3BP, on the secretion of IL-6 during severe COVID-19.