When mannose-binding lectin recognizes an invading pathogen, it initiates the lectin complement cascade by activating MASP-2 and its counterpart, MASP-1. When MASP-2 and MASP-1 are activated, they ...

The mannose-binding lectin pathway can be activated by C3 hydrolysis or antigens without the presence of antibodies (non-specific immune response). In all three pathways, C3-convertase cleaves and ...

The amount of each of the more than a thousand different glycoproteins in your blood varies widely with the 10 most abundant ...

Until now the autoactivating mannose-binding lectin-associated serine protease (MASP)-2 has been considered the autonomous initiator of the proteolytic cascade. The role of the much more abundant MASP ...

The lectin pathway, and MBL in particular, seems to be an essential component of the inflammatory process leading to additional post-ischemic damage after stroke in mice and humans.

Epidemiology and Infection, Vol. 142, No. 10 (OCTOBER 2014), pp. 2195-2206 (12 pages) Several studies have evaluated the association between mannose-binding lectin (MBL) polymorphisms and sepsis.

In addition to a role in the lectin pathway, MASP-2 is involved in the coagulation cascade. It can cleave prothrombin to produce thrombin, which is central to the formation of a blood clot. MASP-3 ...

The amount of each of the more than a thousand different glycoproteins in your blood varies widely with the 10 most abundant ...

Chronic liver disease is a major complication of cystic fibrosis (CF) and factors other than the deletion of ΔF508 (which causes CF) may control the development of liver damage. In May Journal of ...

The mannose-binding lectin pathway can be activated by C3 hydrolysis or antigens without the presence of antibodies (non-specific immune response). In all three pathways, C3-convertase cleaves and ...