The lectin pathway is one of three pathways by which the complement system can be activated. This pathway is initiated by the binding of mannose-binding lectin (MBL), collectin 11 (CL-K1), and ...

Complement Alternative and Mannose-Binding Lectin Pathway Activation Is Associated With COVID-19 Mortality Federica Defendi 1* Corentin Leroy 2,3 Olivier Epaulard 4,5 Giovanna Clavarino 1 Antoine ...

The lectin pathway involves carbohydrate recognition by pattern-recognition receptors, such as mannose-binding lectin and ficolins, and the subsequent activation of associated unique enzymes that ...

Background—The involvement of the complement system in brain injury has been scarcely investigated. Here, we document the pivotal role of mannose-binding lectin (MBL), one of the recognition molecules ...

When mannose-binding lectin recognizes an invading pathogen, it initiates the lectin complement cascade by activating MASP-2 and its counterpart, MASP-1. When MASP-2 and MASP-1 are activated, they ...

The mannose-binding lectin pathway can be activated by C3 hydrolysis or antigens without the presence of antibodies (non-specific immune response). In all three pathways, C3-convertase cleaves and ...

Methods and Results— Monoclonal antibodies (mAbs; P7E4 and 14C3.74, IgG1κ isotypes) were raised against rat mannose-binding lectin (rMBL). Both mAbs recognized rMBL-A by Western analysis or surface ...

There are three pathways involved in activation of complement, one of which is the lectin pathway, whose primary component is the protein MBL (mannose-binding lectin). MBL, which is coded by the gene ...

Mannose-binding lectin may activate complement by means of the lectin pathway when interacting with mannose-binding lectin–associated serine proteases and can directly opsonize pathogens and ...

The complement system is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promotes ...