The lectin pathway involves carbohydrate recognition by pattern-recognition receptors, such as mannose-binding lectin and ficolins, and the subsequent activation of associated unique enzymes that ...

The complement system is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promotes ...

MASP-2 is a crucial enzyme within the lectin pathway. Only MASP-2 can cleave both C4 and C2. ... Mannose-binding Lectin and MASP-2 Prevent SARS-CoV-2 Spread.

Critically ill children are susceptible to nosocomial infections, which contribute to adverse outcomes. Deficiencies in the innate immunity lectin pathway of complement activation are implicated ...

Activation of the lectin pathway of complement is mediated by mannose-binding lectin, which is a pattern-recognition receptor specific for microbial carbohydrates.

The lectin pathway is homologous to the classical pathway, but with the opsonin, mannose-binding lectin (MBL) and ficolins, instead of C1q. The FDA has now approved seven indications for ...

Narsoplimab, Omeros’ investigational human monoclonal antibody targeting mannan-binding lectin-associated serine protease-2 (MASP-2), the key effector of the lectin pathway of complement, was ...

In May Journal of Medical Genetics Gabolde and colleagues from Hôpital Robert Debré, Paris report that an independent genetic factor — the mannose binding lectin (MBL) gene — influences the severity ...

Mannose-binding lectin alleles were genotyped by means of a polymerase-chain-reaction assay in 91 Danish patients with SLE. Arterial and venous thromboses occurring after the diagnosis of SLE were ...