Before looking at the various strategies which make use of the nitro-Mannich reaction in target-oriented synthesis, we will consider briefly what factors have to be kept in mind when planning a ...

The researchers found that the catalytic Mannich reaction is an effective method to synthesize chiral imidazolines from α-isocyanoacetates and ketimines.

This protocol describes a procedure for the synthesis of α, β-branched-b-amino aldehydes via Proline-catalyzed asymmetric Mannich reaction of aldehydes with N-tert–butoxycarbonyl-imines. The ...

Letter Published: 20 February 2008 Proline-catalysed Mannich reactions of acetaldehyde Jung Woon Yang, Carley Chandler, Michael Stadler, Daniela Kampen & Benjamin List Nature 452, 453–455 (2008 ...