Mannan-binding lectin–deficient serum (<20 ng of mannan-binding lectin per milliliter) was obtained from two healthy volunteers. Serum samples from 17 patients who had hypocomplementemia with ...

Mannan-binding lectin (MBL) plays a key role in the lectin pathway of complement activation and can influence cytokine expression. Toll-like receptor 4 (TLR4) is expressed extensively and has been ...

Narsoplimab, via MASP-2 inhibition, blocks lectin pathway activation while leaving the adaptive immune (ie, the classical pathway) response intact and fully functional. 15 Herein, we report safety and ...

Mannose-binding lectin is associated with the serine proteases mannan-binding lectin–associated proteases 1 and 2 (MASP1 and MASP2). Binding of mannose-binding lectin to its microbial ligands ...

Narsoplimab targets mannan-binding lectin-associated serine protease-2 (MASP-2), the effector enzyme of the lectin pathway of complement, and has received breakthrough therapy designations and ...

Another mode of activation is the mannan-binding lectin pathway (MB-lectin pathway). That is initiated by binding of the serum protein mannan-binding lectin to mannose-containing carbohydrates on ...

The discovery announced today further expands Omeros' mannan-binding lectin associated serine protease-2 (MASP-2) program and may permit the development of new antibodies to treat disorders that ...

41 In brief, diluted serum samples are incubated in mannan-coated microtitre wells to allow for the binding of MBL-MASP complexes. This is performed in a buffer allowing for the binding of MBL ...

Fuzuloparib Maintenance Therapy in Patients With Platinum-Sensitive, Recurrent Ovarian Carcinoma (FZOCUS-2): A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Trial In this single ...