When functional, a lysosome can break down large sugars into small sugars, which are then used as an energy source. In LSDs, these macrophage lysosomes become swollen and filled with waste.

In endocytosis, the cell takes in materials from outside by wrapping them within vesicles, which carry them to the lysosome for breakdown. In phagocytosis, immune cells such as macrophages act ...

According to biology textbooks, a macrophage engulfs a bacterium, internalizes it in a toxin-filled vesicle called a phagosome, then shuttles the cellular remains to a lysosome for degradation. But ...

Lysosome-related organelles (LROs ... As the LPS signal is mediated through TLR4 on DCs and macrophages, and these cells do not typically express granzymes, it will be interesting to unravel ...