It tells the cell, ‘Hey, we have a problem here.’ This alert system then recruits another group of proteins called ORPs.” The ORPs (oxysterol-binding protein (OSBP)-related protein) connect the ...

Journal reference: Senol, A D., et al (2021) α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes.

More information: Kangfu Peng et al, The autophagy protein ATG-9 regulates lysosome function and integrity, Journal of Cell Biology (2025). DOI: 10.1083/jcb.202411092 ...

A research team led by the University of Cincinnati's Atsuo Sasaki, PhD, has received a $1.6 million National Institutes of Health research project grant (R01) to learn more about how an enzyme ...

Thus, by impairing lysosomal function α-syn fibrils block their own degradation in lysosomes, that instead become a hub for the propagation of the pathology.