Missing pathway in lysosome underlies newly discovered human disease Date: October 6, 2022 Source: University of Michigan Summary: In a rare disease called mucolipidosis type II, people's hearts ...

Researchers at Duke-NUS Medical School and colleagues in Singapore have identified a protein that transports degraded membrane lipids out of lysosomes, cellular organelles that are the breakdown ...

Lysosomes are organelles normally deputed to the degradation and recycling of toxic/damaged cell material." Chiara Zurzolo, Head, Membrane Traffic and Pathogenesis Unit, Institut Pasteur ...

To pinpoint the individual components of the missing pathway, Tan used a lentivirus to express an enzyme called Turbo-ID in human cells, which sticks a biotin tag onto any protein within a ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes ...

"Interestingly, in cancer cells that are less susceptible to ferroptosis, lipid peroxidation occurred in the lysosomes, but this did not lead to lysosomal membrane damage," continues Yamada.

Researchers from Tokyo Medical and Dental University (TMDU) have demonstrated direct homophilic interaction of lysosomal-associated membrane protein 2 (LAMP2). They found that the two-domain ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes ...

"Interestingly, in cancer cells that are less susceptible to ferroptosis, lipid peroxidation occurred in the lysosomes, but this did not lead to lysosomal membrane damage," continues Yamada. "Upon ...