Figure 1: Mitochondria and lysosomes form stable membrane contact ... which can no longer maintain stable contacts. For electron microscopy (EM), cells were grown on coverslips and fixed in ...

[Courtesy of Tian et al., bioRxiv, 2021.] Lipofuscin Pile-Up. Without prosaposin, electron-dense granules of lipids and iron clogged lysosomes of human neurons. [Courtesy of Tian et al., bioRxiv, 2021 ...

Scientists led by Mikael Simons of the German Center for Neurodegenerative Diseases in Munich report that, within the bowels of microglial lysosomes ... they were able to form independently. Under the ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes.

"By using super-resolution and electron microscopy, we found that α-syn fibrils affect the morphology of lysosomes and impair their function in neuronal cells. We demonstrated for the first time ...

Transporters like cystinosin move the amino acids out of lysosomes - the cellular compartments where proteins are broken down - into the cell to be reused. When cystinosin isn't functioning ...

Only the development of faster electron microscopic techniques ("3D EM") and of more efficient image analysis routines has made the dense mapping of neuronal networks possible. The novel field of ...