Delving deeper, the researchers found that blocking autophagosome-lysosome fusion and autolysosomal degradation (the downstream steps of autophagy) abrogated 6-OHDA-induced PARK7 secretion ...

Dublin, April 11, 2022 (GLOBE NEWSWIRE) -- The "Targeted Protein Degradation by Proteasomal, Lysosomal & Autophagy Pathways 2022: An Industry Landscape Analysis of Stakeholders, Technologies ...

(5) Canonical autophagosomes envelop mitochondria for lysosomal degradation via PINK1-PARKIN dependent or independent manner. (6) Lysosomes directly take up mitochondria by the lysosomal membrane ...

From the screen, the team identified two pathways that impacted LYTAC-mediated degradation. Firstly, they found that degradation was blocked by the post-translational modification of proteins with a ...

They also developed a novel assay that detects how ɑ 2 M mediates the lysosomal degradation of targeted proteins. The group's findings were published online on March 28, 2023, in Volume 13 of ...

More information: Isidoro Cobo et al, Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression, Immunity ...

In 2020, Stanford ChEM-H researchers pioneered a way to reach the other 40% of those proteins through lysosome targeting chimeras (LYTACs), which can identify and mark proteins that are hanging ...

We found that the paternal mitochondrial elimination process (PME) is conserved in C. elegans and that the maternal autophagy/lysosomal pathway and the proteasome degradation pathway actively ...

If we inhibit PIKfyve, the cells are now forced to make their own fats, and the relevant genes are turned on." The team demonstrated that tumor cells make new fat through the KRAS-MAPK pathway.