Clinical Clue: Systemic symptoms (e.g., proteinuria, cardiomyopathy). Radiation Colitis: Acute: Crypt atrophy, nuclear atypia, eosinophil-rich inflammation.

More information: Ellie E. Miles et al, Physical Activity, Symptoms, Quality of Life and Exercise Program Preferences in People With Chronic Lymphocytic Leukaemia, eJHaem (2025).

Patient 14 had clinical remission on methotrexate 7.5 mg weekly, but when the dose was reduced to 5 mg weekly symptoms recurred. When the dose was increased to 7.5 mg symptoms rapidly resolved again.