Nature Reviews Cardiology - Aortic root dilatation reduced with losartan use in patients with Marfan syndrome Skip to main content Thank you for visiting nature.com.

Progressive dilation of the aortic root is considered one of the most serious manifestations of Marfan syndrome. The antihypertensive losartan is one of the two medications recommended by current ...

CHICAGO — Children and young adults with Marfan syndrome had a similar rate of aortic root dilation during 3 years after treatment with losartan or atenolol.Ronald V. Lacro, MD, from the ...

AMSTERDAM — Losartan, an angiotensin II receptor antagonist, reduced the rate of aortic enlargement in patients with Marfan syndrome, according to data presented at ESC Congress 2013.

In this randomized trial comparing losartan with atenolol in a large cohort of children and young adults with Marfan's syndrome and a dilated aortic root, we found no significant difference in the ...

Beta-blockers have been the standard treatment for people with Marfan's syndrome, a rare inherited connective tissue disorder that affects about 1 in 5000 people. The goal of treatment is to ...

The mean (±SD) rate of change in aortic-root diameter decreased significantly from 3.54±2.87 mm per year during previous medical therapy to 0.46±0.62 mm per year during ARB therapy (P<0.001).

The Atenolol vs. Losartan in Children and Young Adults with Marfan Syndrome study was a randomized study that enrolled 608 patients aged 6 months to 25 years from 2007–2011 across 21 clinical ...

Losartan, a common blood-pressure lowering medication, is routinely used prophylactically by Marfan patients to help prevent or delay aortic root disease. Advertisement ...

The lead investigator for the COMPARE study says, since blood-pressure lowering is already recommended in this group, losartan could be recommended to these patients.

The researchers found that the MFS/ATR1a-null mice showed unabated aortic root enlargement and remained responsive to losartan, despite being hypotensive and resistant to AngII vasopressor effects ...

Progressive dilation of the aortic root is considered one of the most serious manifestations of Marfan syndrome. The antihypertensive losartan is one of the two medications recommended by current ...