Local anesthetic systemic toxicity (LAST) is estimated to occur in 1 of 1000 local anesthetic administrations 1, 2 It results from supratherapeutic levels of local anesthetic in the bloodstream. Most ...

Treatment for LAST includes airway management, circulatory support and promoting the diminution of the systemic effects of local anesthetics. Read the ASRA practice advisory on local anesthetic ...

Source Reference: Fettiplace M, et al "The impact of local anesthetic systemic toxicity advisories on reporting to the National Poison Data System (NPDS)" Reg Anesth Pain Med 2025; DOI: 10.1136 ...

Toxicity symptoms in awake adults develop at lidocaine levels of 4.5–7.5 μg/mL. Increasing levels of local anesthetic correlate with a progression of symptoms, including circumoral paresthesia, ...

Local anesthetics are widely used for pain control, but carry an inherent risk of systemic toxicity, referred to as LAST, prompting multiple professional societies to issue recommendations in 2010 ...

Local anesthetics are widely used for pain control, but carry an inherent risk of systemic toxicity, referred to as LAST, prompting multiple professional societies to issue recommendations in 2010 ...

In the same period, overall reports of local anesthetic poisonings decreased by 23% (OR 0.77, 95% CI 0.76-0.78, P <0.0001), driven by a drop in non-lidocaine reports, the researchers reported in ...

The American Society of Regional Anesthesia and Pain Medicine has published a practice advisory on local anesthetic systemic toxicity (LAST) called “Guidelines for the Management of Severe Local ...