The pivotal Phase II trial is testing Allogene’s CAR T candidate cemacabtagene ansegedleucel for large B-cell lymphoma.

The researchers discovered a crucial biological mechanism by studying mouse embryo development. They found that during a specific stage of liver development (between embryonic days 10 and 11), mouse ...

To determine the cell state at which St. Jude B-ALL samples transformed, Mullighan's scientists needed to map normal hematopoiesis (blood cell development) at the single-cell level.

Analysis of liver sinusoidal endothelial cells (“LSEC”) from screening and end of treatment biopsies in the Phase 2b NATIVE study showed evidence of LSEC capillarization in patients without ...

Liver cells, so-called hepatocytes, make up about 60 percent of the total cell number of the organ. They have important metabolic tasks and are active in detoxification and metabolism.

To determine the cell state at which St. Jude B-ALL samples transformed, Mullighan's scientists needed to map normal hematopoiesis (blood cell development) at the single-cell level.

Among the patients who underwent surgery, 21 percent had at least one “major adverse liver outcome” by 15 years, compared with 46 percent of those who did not have surgery.