In the healthy liver, most macrophages are classified as Kupffer cells (KCs). However, upon liver injury, as seen, for example, in obesity, another subset of macrophages called lipid-associated ...

A study conducted by Prof. Thai-Yen Ling at National Taiwan University underscores the potential of small extracellular ...

Moreover, the cells and soluble factors participating in this response in liver are also similar to those in parenchymal injury to kidney, lung, or skin. Fibrosis occurs earliest in regions where ...

Bile duct inflammation and scarring, known as cholangiopathies, can disrupt bile flow, leading to liver damage and ...

Scientists at Massachusetts General Hospital have revealed how chronic liver injury alters hepatic stellate cells (HSCs), triggering the formation of fibrotic scarring in the liver. The researchers ...

The team then administered two drugs, RIPA-56 1 to block the RIPK1 pathway and YAQ-005 to prevent the activation of the TLR4 pathway, which led to significant reduction in liver injury and cell ...

The cells show characteristic liver-specific functions and only small ... “However, major injury like long-term virus infection, alcoholic damage and drug damage may need more drastic measures.” ...

the liver has stem cells that both proliferate and give rise to mature cells, even in the absence of injury or disease.” Nusse and his colleagues reported their findings August 5, 2015, in the journal ...

BioHarvest demonstrated that in human hepatic (liver) cells, the Olive Cell compound ... which includes hepatocellular injury, inflammation, and fibrosis. In more severe cases, complications ...

Ammonia buildup damages liver cells by harming mitochondria, leading to cell death and liver injury. An existing drug, YAQ-005, can prevent this damage by halting mitochondrial harm, allowing ...

High levels of ammonia kill liver cells by damaging the mitochondria that power the cells. But this can be prevented using an existing drug due to start clinical trials, finds a new study in mice.