Article citations More>> Brunk, U.T. and Terman, A. (2002) Lipofuscin: Lipofuscin: Mechanisms of Age-Related Accumulation and Influence on Cell Function. Free Radical Biology and Medicine, 33, 611-619 ...

Significance Regarding basic science, we report a physical chemistry mechanism involved in turnover of spent photoreceptor discs, a process essential for reusing retinal and preventing lipofuscin that ...

A common mechanism in two forms of neurodegeneration that affect young adults or the elderly has now been identified by researchers. The discovery advances efforts to find better treatments and ...

H 2 O 2 -induced oxidative stress and the TRF treatments had no effect on the protein carbonyl content in C. elegans (Figure 4B). Figure 4 Effect of TRF on accumulation of (A) lipofuscin, (B) protein ...

We have observed pigmented cytoplasmic granules, with the characteristic staining properties of lipofuscin (ceroid, "wear-and-tear") pigment, in newborn human liver. The pigment is found at the ...

There is increasing evidence that proteostasis is disturbed in RPE as evidenced by lysosomal lipofuscin and extracellular drusen accumulation in AMD. Nuclear factor-erythroid 2-related factor-2 ...

“We knew visible light could damage the skin, but we’ve gained a deeper understanding of the mechanisms by showing that UVA stimulates accumulation of a pigment called lipofuscin, which later acts as ...