This bioinformatics-assisted review describes key biological elements of known pathways, such as the forkhead box protein O1/leptin receptor and Janus kinase/signal transducer and activator of ...

This bioinformatics-assisted review describes key biological elements of known pathways, such as the forkhead box protein O1/leptin receptor and Janus kinase/signal transducer and activator of ...

Results In obese patients with diabetes, metreleptin administration for 16 weeks did not alter body weight or circulating inflammatory markers but reduced HbA 1c marginally (8.01 ± 0.93–7.96 ± ...

The discovery in 1994 of leptin, an appetite-suppressing hormone produced by fat cells, led to hopes that the peptide could be used to treat obesity pharmacologically. However, it soon emerged that ...