Hayat, Azam. (2012). The Molecular Interactions between Two Activation Pathways of Complement are Essential for a Protective Innate Immune Response to Neisseria Meningitidis Infection.

The three pathways of activation all generate homologous variants of the protease C3-convertase. The classical complement pathway typically requires antigen—antibody complexes (immune complexes) for ...

None of the blood samples contained SARS-CoV-2 antibodies, thus eliminating any antibody-mediated classical pathway activation of complement. C3, C5, and heparan sulfate inhibitors are not capable ...

The mannose-binding lectin pathway can be activated by C3 hydrolysis or antigens without the presence of antibodies (non-specific immune response). In all three pathways, C3-convertase cleaves and ...

Therefore, they concluded that, “Complement suppression may represent a common therapeutic approach for pneumonia induced by these highly pathogenic coronaviruses.” A promising drug candidate that ...

Its pathogenesis is complex and not well understood, but there is increasing evidence that the lectin-driven complement activation may be behind it. Mannose-binding lectin serine protease 2 (MASP-2) ...

In addition to its lectin pathway inhibitors, the company is advancing its development of antibodies and small-molecule inhibitors against MASP-3 to block activation of the alternative pathway.