In addition to its lectin pathway inhibitors, the company is advancing its development of antibodies and small-molecule inhibitors against MASP-3 to block activation of the alternative pathway.

The panel discussed the emerging evidence that endothelial injury and the activation of the lectin pathway of complement are central drivers of the acute respiratory distress syndrome (ARDS) and ...

Its pathogenesis is complex and not well understood, but there is increasing evidence that the lectin-driven complement activation may be behind it. Mannose-binding lectin serine protease 2 (MASP-2) ...

Three pathways have now been described in the complement system — the classic, alternative and lectin. A fourth, lytic pathway is added by some authors for membrane attack complex.

TST004 is a humanized mAb targeting mannose-binding protein-associated serine protease 2 (MASP2) and designed to prevent the lectin pathway complement-mediated inflammation. Transcenta discovered ...

In the lectin pathway, carbohydrate epitopes on microbes are recognized. The third is the alternative pathway, which is an amplifier of those two pathways.

Therefore, they concluded that, “Complement suppression may represent a common therapeutic approach for pneumonia induced by these highly pathogenic coronaviruses.” A promising drug candidate that ...

Hayat, Azam. (2012). The Molecular Interactions between Two Activation Pathways of Complement are Essential for a Protective Innate Immune Response to Neisseria Meningitidis Infection.