Image Credit: ACROBiosystems Complement activates three pathways, despite the lack of specificity of the components of the acquired immune system: the lectin pathway, the classical pathway ...

Eleven of the 17 patients studied had anti-C1q autoantibodies. No patient had reduced activity of the mannan-binding lectin pathway. Autoantibody against MASP-2 did not appear to be the cause of ...

the alternative complement pathway, and the lectin pathway. Most of the proteins and glycoproteins that constitute the complement system are synthesized by hepatocytes. But significant amounts are ...

Mannose-binding lectin serine protease 2 (MASP-2) has been studied as a therapeutic target in the treatment of IgA nephropathy, as it is one of the main lectin pathway activators.

Omeros aims to make narsoplimab, which targets the lectin pathway’s effector enzyme MASP-2, the first approved treatment for TA-TMA. "The results of this comparative survival analysis for ...