No patient had reduced activity of the mannan-binding lectin pathway. Autoantibody against MASP-2 did not appear to be the cause of the MASP-2 deficiency in our patient, since antibodies against ...

For example, defects in the interferon-γ pathway have been implicated ... One exception is deficiency of mannose-binding lectin (MBL), which leads to defective complement activation.

Omeros’ OMS721 is a human monoclonal antibody that inhibits MASP-2, which is the effector enzyme of the lectin pathway of the complement system. Omeros controls the worldwide rights to MASP-2 ...

OMS721 selectively inhibits MASP-2, blocking the lectin pathway of the complement system ... not appear to be detrimentally affected by the deficiency. Therefore, Omeros believes that it may ...

"However, we didn't see this same immune cell uptake in mice with a very specific deficiency ... There are three pathways that activate the complement system: Lectin, classical and alternative.

Mannose-binding-lectin deficiency associated with arterial thromboses only They genotyped 91 patients with SLE and found that 54 had no mannose-binding-lectin variant alleles (A/A genotype), 30 ...

the alternative complement pathway, and the lectin pathway. Most of the proteins and glycoproteins that constitute the complement system are synthesized by hepatocytes. But significant amounts are ...

20 The exons of MASP2 in three Zambians with very low MASP-2 levels (sample 26:37 ng/ml, sample 138:48 ng/ml and sample 198:85 ng/ml) and with deficiency ... of the lectin pathway, which ...