This enzyme can work only in the 5' to 3' direction, so it replicates the leading strand continuously. Lagging-strand replication is discontinuous, with short Okazaki fragments being formed and ...

As the leading strand T7 replisome does not pause during primer synthesis, this cannot explain why the leading and lagging strands are synthesized at the same rate. However, ...

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies published in the journals ...

In diseases like cancer, these mechanisms can fail, leading to uncontrolled or faulty replication with devastating consequences. ... resulting in two strands called the leading and lagging strands.

The findings visualize for the first time a molecular complex -; called CTF18-RFC in humans and Ctf18-RFC in yeast -; that loads a "clamp" onto DNA to keep parts of the replication machinery from ...

The polymerase on the “leading strand” can easily work at a continuous pace, but the polymerase on the “lagging strand” cannot. Until now, scientists believed that the polymerases on the ...

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies. The findings visualize for ...

The process begins by unzipping DNA's ladder-like structure, resulting in two strands called the leading and lagging strands. A molecular construction crew then assembles the missing halves of the ...