Normally for the lagging strand, DNA synthesis is unhindered, and the replisome starts synthesizing the last Okazaki fragments along the 3’ overhang that are later stitched together to prevent ...

The PCNA–Pol δ complex couples lagging strand DNA synthesis to parental histone transfer for epigenetic inheritance Journal: Science Advances Published: 2024-06-07 DOI: 10.1126/sciadv.adn5175 ...

Journal References: Zuanning Yuan, Roxana Georgescu, Nina Y. Yao, Olga Yurieva, Michael E. O’Donnell, Huilin Li. Mechanism of PCNA loading by Ctf18-RFC for leading-strand DNA synthesis. Science ...

Telomerase solves this problem by adding single-stranded TTAGGG repeats to the telomere end. As for the lagging-strand, DNA synthesis should not have a problem.

That is how Harold P. de Vladar, CEO and founder of long-synthetic DNA service provider Ribbon Biolabs, sees the vast opportunity in the DNA synthesis space. de Vladar says that the DNA synthesis ...