Researchers at the University of Tsukuba have developed a vector that integrates the Cre enzyme gene with the specific DNA ...

In particular, researchers often turn to mice because of all the various model organisms most commonly ... geneticists can generate knockout mice in which the mouse counterpart of a human gene ...

Knockout mice are used to study what happens in an organism when a particular gene is absent. Studying knockout mice can provide information about how the knocked-out gene normally functions ...

Rationale.The central nervous system (CNS) is the most complex structure of the animal organism both in terms of its development ... gene by generating and systematically phenotyping ~20,000 knockout ...

Mice and newts were applied to the one-step Cre-loxP organism creation technology by TAx9. In this study, the researchers succeeded in synthesizing a Cre-loxP integrated vector by placing a short ...