Lower kininogen concentration in plasma correlate with a higher APACHE II score in septic patients. We show that ASO-mediated depletion of kininogen in mice indeed restrains streptococcal spreading, ...

The relationship of kininogen to epileptogenesis has not been explored previously. Although we did not examine whether early stage elevation of kininogen in CSF contributes to the development of ...

Objective— Plasma high-molecular-weight kininogen (HK) is cleaved in inflammatory diseases by kallikrein to HKa with release of bradykinin (BK). We postulated a direct link between HKa and ...

Herein, changes in kininogen levels in the hippocampus (Figures 3A–C) but not in the cortex (Figures 3D–F) suggest that the regulation of kininogen synthesis and/or degradation takes place in the ...

Acquired high molecular weight kininogen (HK) deficiency is extremely rare. Antibody Baltimore is an antibody to factor XI that blocks high molecular weight kininogen binding and factor XIIa ...

Kininogen expression by rat vascular smooth muscle cells: Stimulation by lipopolysaccharide and angiotensin II. Biochim Biophys Acta 1404: 329–337. Article CAS PubMed Google Scholar ...

Furthermore, exogenously added T-kininogen inhibited the activation of the ERK pathway induced by either bradykinin or T-kinin. We conclude that the age-related increase in hepatic T-kininogen gene ...

High molecular weight kininogen deficiency is quite rare; it is the least common of all the blood coagulation proteins deficiencies. In North America, it has only been seen in individuals with an ...