AHMEDABAD: The state tourism department has been violating the state government’s own forest laws and allowing numerous tourists to halt at night in the Kankai temple located in the heart of Gir ...

RAJKOT: The trustees of Kankai temple located in dense Gir forest have alleged that forest officials vandalized their water pipeline on the midnight of Friday and threatened them with penal action ...

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature, 2021; DOI: 10.1038/s41586-021-03539-7 ...

"This DHODH treatment target is full of promise, but it will take several years before we can reach the clinical trial stage. This potential new treatment, unlike current ones, will not be toxic ...

This important study reports a novel mechanism linking DHODH inhibition and subsequent pyrimidine nucleotide depletion with upregulation of cell surface MHC I in cancer cells. The in vitro mechanistic ...

Dihydroorotate dehydrogenase (DHODH) is an attracting target for the treatment of immunological diseases. A series of acrylamide-based novel DHODH inhibitors as potential rheumatoid arthritis (RA ...

In their manuscript entitled "DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation", Mullen et al. describe an interesting mechanism of ...

Inhibition of DHODH is an established mechanism for the treatment of autoimmune conditions, notably relapsing-remitting multiple sclerosis (RRMS). First generation DHODH inhibitors have limited ...