The Krebs cycle byproduct itaconate regulates immune cell function, however its role within tumor cells remains unclear. Here ...

A tiny molecule called itaconate plays an especially important role in this." Itaconate is an anti-inflammatory substance ...

My laboratory is focused on understanding and manipulating the interaction of host immunity with biomaterial implants. Synthetic polymers provide the foundation to diverse medical devices in the ...

By inhibiting bacterial itaconate-degrading enzymes, her work has demonstrated the ability to sensitize bacteria to natural antimicrobials produced by mammalian macrophages, leading to significant ...