For the first time, scientists have identified promising drug candidates that bind irreversibly with a notoriously ...

As a reversible inhibitor, harmine temporarily binds to monoamine oxidase A, allowing the enzyme to function again once harmine is metabolized (in contrast, irreversible inhibitors permanently ...

Conclusion: Rasagiline is an investigational selective and irreversible inhibitor of MAO-B that has demonstrated efficacy and safety for the treatment of PD. Whether rasagiline is associated with ...

The irreversibility of cell-cycle transitions is commonly thought to derive from the irreversible degradation ... By applying a second inhibitor (flavopiridol) that blocks the activity of Cdk ...