Here, in bone marrow transplantation and organoid culture models, T-cell-derived Interferon-γ is shown to promote STAT1-dependent intestinal stem cell c-MYC expression and epithelial regeneration.

More information: Jaakko Mattila et al, Stem cell mTOR signaling directs region-specific cell fate decisions during ...

I don't necessarily think about normal stem cells dying when colon cancer is starting,” Sethi commented. To understand the sequence of these early events, the researchers did a timed deletion of one ...

Maternal microbiome-derived metabolites during pregnancy impact offspring stem cell function, offering potential therapeutic targets to improve child health.

The authors examine the role of Numb, a Notch inhibitor, in intestinal stem cell self-renewal in Drosophila during homeostasis and regeneration. This is an important study providing evidence of a Numb ...

the use of new types of stem cells, signaling molecules, and bioactive scaffolds for the tissue-engineered intestine will need to be scrutinized in clinical trials. The expense associated with ...

The activity of tissue stem cells and the pace of tissue renewal varies a lot depending on the tissue. The inside lining of the intestine for example, renews completely approximately in five days when ...

Due to the development of research methods since the early 21st century, it has been possible to demonstrate the existence of stem cells in nearly all organs. The development has led to the discovery ...

The Feinstein Institutes for Medical Research has been awarded a five-year, $2.9 million grant from the National Institutes ...

In addition to mechanistic studies, his lab developed novel organ culture methods to direct differentiation of human pluripotent stem cells into intestinal tissue to study intestinal development and ...