The desmosome-intermediate filament system facilitates mechanotransduction at adherens junctions for epithelial homeostasis Journal: Current Biology Published: 2024-09-09 DOI: 10.1016/j.cub.2024. ...

The desmosome is a specialized adhesive junction that interacts with the cytoskeleton and participates in crosstalk with gap and adherens junctions. Mutations in components of the desmosome underlie a ...

These desmosomes, visualized by antibodies to the protein desmoplakin (red), provide anchorage to the cytoplasmic bundles of intermediate filaments of the keratin type (green).

Abstract Desmosomes and adherens junctions are intercellular adhesive structures essential for the development and integrity of vertebrate tissue, including the epidermis and heart. Their cell ...

More information: Navaneetha Krishnan Bharathan et al, Architecture and dynamics of a desmosome–endoplasmic reticulum complex, Nature Cell Biology (2023). DOI: 10.1038/s41556-023-01154-4 ...

Desmoplakin is a key component of the adhesive junctions, known as desmosomes, that link cells together in tissues that undergo severe strain, such as the heart and skin. Its role is to anchor ...

We report on the application of variations to the traditional TEM processing methods, which provide improved clarity of the desmosome–cytoskeleton complex of MCF-7 human breast cancer cells. A more ...

The desmosome is a specialized adhesive junction that interacts with the cytoskeleton and participates in crosstalk with gap and adherens junctions. Mutations in components of the desmosome underlie a ...