The research highlights the complex role of tryptophan metabolism in cancer ... fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis, Nature Communications (2024).

Indole-based alkaloid natural products such as fischerindoles and hapalindoles have promising antimicrobial and antitumor activities, but they are difficult to make synthetically. New findings on ...

a major rate-limiting enzyme for the pyruvate dehydrogenase complex that regulates pyruvate metabolism from glucose in the mitochondria, in mouse resulted in reduced insulin availability and ...

Rapid and extensive Schwann cell death under high-glucose pyruvate-depleted conditions ... escalation of the polyol and other collateral glycolysis pathways, 4) impaired hexokinase (HK) activity ...

One of the hallmarks of colorectal cancer cells is an altered metabolism that is not associated with tumor-causing mutations. "Pyruvate is known to have an important role in cancer metabolism ...