Immunological synapse (IS) formation is a key part of developing and sustaining immune responses against cancer and is necessary for T cells and NK cells to eliminate tumor cells. This webinar will ...

Details of the poster presentation TitleInhibition of Integrin αvβ8 enhances immune checkpoint induced anti-tumor immunity by acting across immunologic synapse in syngeneic models of breast ...

Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite. Journal: Cancer Cell Published: 2024-06-10 DOI: 10.1016/j.ccell.2024.05.006 Affiliations: 6 ...

They found that CD28.ζ-CAR molecules shuttle through the immune synapse quickly, working within minutes to kill cancer cells. This enabled fast CAR T cell recovery and a mastery of “serial killing” of ...

Journal Science Advances DOI 10.1126/sciadv.adq8114 Article Title Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cells Article Publication Date 10-Jan-2025 ...