A research team has uncovered how glycan modifications dynamically regulate the structure and function of human ...

A folded module has a length of 4.4 nm 17, whereas unfolding of a single immunoglobulin module lengthens a titin molecule abruptly by ∼ 28 nm and immediately relaxes the stretching force 12, 21, 25.

Immunoglobulin M is a large-sized (1.0 MDa) multimeric proteinaceous molecule, the structure of which has been reported to be pentameric or hexameric, the former comprising a joining (J) chain.

Background: Diagnosis of monoclonal gammopathies (MGs) is determined by demonstration of a monoclonal immunoglobulin molecule or chain in serum and/or urine. Previous results on immunofixation ...