1). The organization of mammalian immunoglobulin heavy- and light-chain gene loci is well characterized, but information about the immunoglobulin loci in other vertebrates is fragmentary.

We report that loci in the immunoglobulin heavy chain variable region as well as in the major histocompatibility complex region contribute in a strain-specific manner to the development of ...

The variable region of each immunoglobulin heavy or light chain is encoded in several pieces on the genes. These are called variable (V), diversity (D) and joining (J) segments. Isotypes are ...

However, that assay is limited in that not all patients with monoclonal gammopathy show abnormal free light chain measurements. Within the last year, a novel assay which can identify and quantitate ...

Although the presence of an unmutated IgV H gene is strongly associated with the expression of ZAP-70, ZAP-70 is a stronger predictor of the need for treatment in B-cell CLL. Clinical and basic ...

Immunocytochemical studies of the sorted cells revealed high levels of cytoplasmic α heavy chains without detectable light chains or surface immunoglobulin. Bone marrow biopsy disclosed extensive ...

N6-methyladenosine modification of long noncoding RNAs expressed from the immunoglobulin heavy chain locus regulates DNA rearrangement events necessary for antibody gene diversity [Nair et al., ...

Each immunoglobulin consists of two long protein chains called heavy chains, which are bound to two short protein chains called light chains. When a person has MM, the atypical plasma cells make ...